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产品名称:Biovision抗体价格Beclin 1 Antibody供应

产品型号:Biovison抗体3663-100

产品报价:

产品特点:Beclin 1 Antibody
Alternative Name: BECN1 , GT197 , Beclin-1 , beclin1 , ATG6 , VPS30

Biovison抗体3663-100Biovision抗体价格Beclin 1 Antibody供应的详细资料:

Antibody Target: Beclin 1

Alternative Name: BECN1 , GT197 , Beclin-1 , beclin1 , ATG6 , VPS30

Host: Rabbit

Antibody Type: Polyclonal

Isotype: Rabbit IgG

Immunogen: Synthetic peptide corresponding to residues around amino acid 25 of mouse Beclin 1

Accession#: O88597

Gene ID: 56208

Appearance: Colorless liquid

Concentration: 0.2 mg/ml

Formulation: 100 µg (0.2mg/ml) protein A purified rabbit anti-Beclin 1 polyclonal antibody in phosphate-buffered saline (PBS) containing 1% BSA, 50% glycerol, and 0.02% thimerosal.

Purification: Affinity purified

Species Reactivity: human, mouse

Application: Western blot

Application & Usage: Western blotting (0.5-2 µg/ml). However, the optimal concentrations should be determined individually. Other applications have not been tested. The antibody recognizes ~53 kDa beclin 1 in Jurkat cell lysate. A weak band of ~110 kDa (possibly dimer) can also be observed in Jurkat cells. In mouse intestine tissue lysate, the antibody recognizes a ~100 kDa band (possibly dimer). Reactivity to other species has not been tested.

Storage Temp.: -20 °C

Shipping: gel pack

Background Descriptions: Beclin is a Bcl-2 binding protein. Its structure includes a Bcl-2 binding coiled-coil region, and a leucine-rich nuclear export signal (NES). Beclin protein colocalizes with intracytoplasmic organelles and nuclei in normal COS7 and MCF7 cells. Beclin interaction with Bcl-2 may be involved with host viral defense, since over expression of beclin inhibits Sindbis virus replication and expression of beclin lacking the Bcl-2 binding domain has no antiviral effects.

Handling: The antibody solution should be gently mixed before use.

Usage: For Research Use Only! Not to be used in humans.

 

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